Tatsuro Teraoka

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Excessive release of neurotransmitters is reported to contribute to the delayed neuronal death in animal models of cerebral ischemia. Since evidence is accumulating that N-type voltage-sensitive calcium channels (N-channels) regulate the release of neurotransmitters, we investigated the effects of omega-conotoxin GVIA (omega-CTX), an antagonist of(More)
We attempted to characterize the functional roles of subtypes of voltage-sensitive calcium channels in the brain. The maximal number of [125I]omega-conotoxin GVIA (omega-CTX) binding sites in rat brain associated with N-type calcium channels (N-channels) was approximately 10 times more than that of [3H]-PN200-110 associated with L-type calcium channels(More)
We investigated the effects of antagonists for omega-conotoxin GVIA (omega-CTX)-sensitive N-type voltage-sensitive calcium channels (N-channels) on methylphenidate- and methamphetamine-induced behavior. I.c.v. injection of omega-CTX or neomycin, both N-channel antagonists, caused a dose-dependent inhibition of methylphenidate-induced hypermotility in mice(More)
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