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West syndrome and Lennox-Gastaut syndrome: a survey of natural history.
The West syndrome and the Lennox-Gastaut syndrome are characterized by their onset in infancy and early childhood, intractable seizures occurring almost daily, severe psychomotor retardation, andExpand
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The anterior and the posterior longitudinal ligaments of the lower cervical spine.
The anterior and the posterior longitudinal ligaments (ALL and PLL) of the cervical spine were examined. The ALL and the deep layer of the PLL are continuous, and surround the vertebral body. TheExpand
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KRAS mutational status in Japanese patients with colorectal cancer: results from a nationwide, multicenter, cross-sectional study.
OBJECTIVE KRAS gene mutations are a useful predictive factor for the efficacy of anti-epidermal growth factor receptor therapeutics. Since there were no large-scale studies among Asian populations,Expand
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Cost-effectiveness analysis of EGFR mutation testing and gefitinib as first-line therapy for non-small cell lung cancer.
OBJECTIVES The combination use of gefitinib and epidermal growth factor receptor (EGFR) testing is a standard first-line therapy for patients with non-small cell lung cancer (NSCLC). Here, weExpand
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Tay-Sachs disease: progression of changes on neuroimaging in four cases
SummaryThe neuroradiological findings in four patients with Tay-Sachs disease are described in three phases of the clinical course. The basal ganglia and cerebral white matter show low density onExpand
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Recent trends for drug lag in clinical development of oncology drugs in Japan: does the oncology drug lag still exist in Japan?
BackgroundThis study exhaustively and historically investigated the status of drug lag for oncology drugs approved in Japan.MethodsWe comprehensively investigated oncology drugs approved in JapanExpand
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Cervical spinal cord atrophy associated with spina bifida
We treated three patients with spina bifida who had atrophy of the cervical spinal cord. One patient presented with a gradually progressive paresis of the upper right extremity, and two patientsExpand
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Involvement of anticancer drugs in the relief system for adverse drug reactions in Japan.
OBJECTIVE The compensation scheme for adverse drug reactions in Japan was implemented more than three decades ago as relief system by regulatory agencies. Because of the high frequency of adverseExpand
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Historical and Hygienic Aspects on Roles of Quality Requirements for Antibiotic Products in Japan : Part 3-Introduction of Technology and Knowledge in the Production Process and Quality Control of
In order to investigate the roles of quality requirements for antibiotic products in Japan, from historical and hygienic aspects, we examined and analyzed how technology and knowledge in theExpand
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[Historical and Hygienic Aspects on Roles of Quality Requirements for Antibiotic Products in Japan: Part 1--Development of Antibiotic Products].
Antibiotic products have contributed greatly to keep Japanese people healthy by controlling lethal infections. In the early days, antibiotics such as penicillin and streptomycin were produced usingExpand
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