Tatsuo Ishizuka

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Increased activity of the sympathetic nervous system may be a critical factor in the development of impaired insulin secretion and insulin resistance. We studied the chronic effects of sympathetic inhibition with moxonidine on glucose metabolism in the spontaneously hypertensive genetically obese rat (SHROB). This unique animal model closely resembles human(More)
The molecular mechanisms underlying increased hepatic phosphoenolpyruvate carboxykinase (PEPCK) gene transcription and gluconeogenesis in type II diabetes are largely unknown. To examine the involvement of glucocorticoids and the cis-acting insulin response sequence (IRS, -416/-407) in the genetically obese db/db mouse model, we generated crosses between(More)
Insulin resistance is associated with both obesity and hypertension. However, the cellular mechanisms of insulin resistance in genetic models of obese-hypertension have not been identified. The objective of the present study was to investigate the effects of genetic obesity on a background of inherited hypertension on initial components of the insulin(More)
Gestational diabetes mellitus (GDM) results from an interaction between susceptibility genes and the diabetogenic effects of pregnancy. During pregnancy, mice heterozygous for the lepin receptor (db/+) gain more weight, are glucose intolerant, and produce macrosomic fetuses compared with wild-type (+/+) mothers, suggesting that an alteration in leptin(More)
J.P. Cravens, K. Abe, T. Iida, K. Ishihara, J. Kameda, Y. Koshio, A. Minamino, C. Mitsuda, M. Miura, S. Moriyama, M. Nakahata, S. Nakayama, Y. Obayashi, H. Ogawa, H. Sekiya, M. Shiozawa, Y. Suzuki, A. Takeda, Y. Takeuchi, K. Ueshima, H. Watanabe, S. Yamada, I. Higuchi, C. Ishihara, M. Ishitsuka, T. Kajita, K. Kaneyuki, G. Mitsuka, H. Nishino, K. Okumura, C.(More)
R. Wendell, C. Ishihara, K. Abe, Y. Hayato, T. Iida, M. Ikeda, K. Iyogi, J. Kameda, K. Kobayashi, Y. Koshio, Y. Kozuma, M. Miura, S. Moriyama, M. Nakahata, S. Nakayama, Y. Obayashi, H. Ogawa, H. Sekiya, M. Shiozawa, Y. Suzuki, A. Takeda, Y. Takenaga, Y. Takeuchi, K. Ueno, K. Ueshima, H. Watanabe, S. Yamada, T. Yokozawa, S. Hazama, H. Kaji, T. Kajita, K.(More)
Women who develop gestational diabetes mellitus (GDM) have severe insulin resistance and markedly increased risk to develop subsequent type 2 diabetes. We investigated the effects of pregnancy and GDM on glucose transport activity and the expression and phosphorylation of the insulin receptor and insulin receptor substrate (IRS)-1 in human skeletal muscle(More)
Dehydroepiandrosterone (DHEA) is expected to have a weight-reducing effect. In this study, we evaluated the effect of DHEA on genetically obese Otsuka Long Evans Fatty rats (OLETF) compared with Long-Evans Tokushima rats (LETO) as control. Feeding with 0.4% DHEA-containing food for 2 wk reduced the weight of sc, epididymal, and perirenal adipose tissue in(More)
Several studies have suggested that both testosterone and dehydroepiandrosterone (DHEA) have weight-reducing and antidiabetic effects, especially in rodent studies; however, the precise mechanism of their action remains unclear. Here, we investigated the effect of DHEA on cell growth in adipose tissue. The appearance of senescence-associated β-galactosidase(More)
In man, serum concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) decrease with age after the twenties. For this reason, the decline in DHEA and DHEAS concentrations may be related to the development of some chronic diseases that are prevalent in the older age population. In this study, we evaluate the benefit and safety level of DHEA(More)