Tatsuhito Morita

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BACKGROUND Autophagy is an intracellular bulk degradation process induced by cell starvation. Autophagy was recently reported to be induced by various stresses such as hypoxia, ischemia/reperfusion, toxins, and denatured proteins, and to affect cell survival and death. Light chain 3-II (LC3-II) is specifically located on double membrane-bound autophagosomes(More)
In view of the fact that the detrusor vesicae and external urethral sphincter perform closely synergic functions in micturition, experiments were conducted to explore the action of the pelvic efferent neurons on the external urethral sphincter. The pelvic efferent neurons are generally recognized, by urodynamic assessments and histochemical study with the(More)
A case of systemic lupus erythematosus (SLE) associated with minimal-change nephrotic syndrome (MCNS) is described. A 41-year-old woman with SLE presented with symptoms of nephrotic syndrome. Renal biopsy revealed minor glomerular abnormalities without the deposition of immune complexes. The initial heavy proteinuria promptly decreased after the(More)
A new in vitro method was used to examine the initiation and the propagation of the peristaltic contraction in the renal pelvis and ureter of the pig. The method enabled the direct observation of peristalsis, both microscopically and electrophysiologically. A microscopic ripplelike contraction of a constant frequency was generated spontaneously at the(More)
The subtypes of the muscarinic cholinergic receptor in human detrusor muscle were studied using radioligand binding techniques. It was found that there were significant amount of M1, M2 and M3 receptors labeled by 3H-pirenzepine, 3H-AFDX and 3H-4DAMP, respectively, in human detrusor muscle. The rank order of the amount of these receptors was M3 > M1 > or =(More)
A new method is described which enables in vivo recording of electromyogram from the pelvicalyceal border (PC border) of the canine renal pelvis. At the PC border slow rising-potentials with constant intervals are recorded throughout the normo-uretic stage and the diuretic stage. The wave form of the discharge is very similar to that of the pacemaker(More)
The functional activity of the sphincter muscle of the urethra is known to be controlled largely by the hypogastric and pudendal nerves. It remains unknown, however, whether innervation of the muscle by these peripheral nerves is ipsi- or bilateral. In an attempt to answer this question urethral closure pressure was determined simultaneously in the(More)
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