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C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase.
- Natsumi Okazaki, K. Hazeki, T. Izumi, K. Nigorikawa, O. Hazeki
- Biology, Medicine
- Journal of biochemistry
- 1 March 2011
The complement system is a classic central player in innate immunity. Most pathogens activate both complement and the toll-like receptor (TLR) pathway. Therefore, to provide a more comprehensive… Expand
Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis
- T. Maekawa, Y. Osawa, +17 authors F. Kimura
- Biology, Medicine
- Leukemia
- 3 April 2017
Myelofibrosis (MF) may be caused by various pathogenic mechanisms such as elevation in circulating cytokine levels, cellular interactions and genetic mutations. However, the underlying mechanism of… Expand