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Comparative studies of the tetrapod raldh2 (aldh1a2) gene, which encodes a retinoic acid (RA) synthesis enzyme, have led to the identification of a dorsal spinal cord enhancer. Enhancer activity is directed dorsally to the roof plate and dorsal-most (dI1) interneurons through predicted Tcf- and Cdx-homeodomain binding sites and is repressed ventrally via… (More)
Despite extensively divergent morphologies, the patterning of the embryonic brain is controlled by highly conserved genetic networks. Orthodenticle and empty spiracles-related homeodomain genes, which are expressed in insects as in vertebrates in anteriormost neuromeres of the embryonic brain, provide examples of such conservations. In gnathostomes, they… (More)
AND KEYWORDS Abstract Recent literature on sustainable logistics networks points to two important questions: (i) How to spot the preferred solution(s) balancing environmental and business concerns? (ii) How to improve the understanding of the trade-offs between these two dimensions? We posit that a complete exploration of the efficient frontier and… (More)