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Acetylation of nucleosome histones results in relaxation of DNA and its availability for the transcriptional regulators, and is generally associated with the enhancement of gene expression. Although(More)
The molecular mechanisms of neuroprotection during hypoxic action involve induction of antioxidants, including manganese superoxide dismutase (Mn-SOD). Previously, we demonstrated that severe(More)
Severe hypoxia results in functional and structural injury of the brain. A preconditioning with repetitive episodes of mild hypoxia considerably ameliorates neuronal resistance to subsequent severe(More)
In the early 1980s, the phenomenon of delayed neuronal death several days after ischemia was described in hippocampal neurons [1]. It was then demonstrated that the neuronal injury observed developed(More)
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