Tatiana V Ramanouskaya

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The RUNX1-RUNX1T1 fusion gene, a product of the nonhomologous balanced translocation t(8;21)(q22;q22), is a complex genetic locus. We performed extensive bioinformatic analysis of transcription initiation as well as transcription termination sites in this locus and predicted a number of different RUNX1T1 transcripts. To confirm and quantify the RUNX1T1 gene(More)
The t(8;21) translocation is the most widespread genetic defect found in human acute myeloid leukemia. This translocation results in the RUNX1-RUNX1T1 fusion gene that produces a wide variety of alternative transcripts and influences the course of the disease. The rules of combinatorics and splicing of exons in the RUNX1-RUNX1T1 transcripts are not known.(More)
Micro RNAs are small, noncoding RNAs involved in the regulation of gene expression in eukaryotes. Being transcribed in the nucleus in the form of a long primary precursor, a primary microRNA undergoes multistep biogenesis that leads to the formation of a mature microRNA. One of the critical biogenesis steps is the recognition and processing of primary(More)
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