Tatiana V. Polushina

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Schizophrenia is a serious psychotic disorder, with disabling symptoms and markedly reduced life expectancy. The onset is usually in late adolescence or early adulthood, which in time overlaps with the maturation of the brain including the myelination process. Interestingly, there seems to be a link between myelin abnormalities and schizophrenia. The(More)
Array comparative genomic hybridization (aCGH) is one of the techniques that can be used to detect copy number variations in DNA sequences in high resolution. It has been identified that abrupt changes in the human genome play a vital role in the progression and development of many complex diseases. In this study we propose two distinct hybrid algorithms(More)
A deoxyribonucleic acid (DNA) sequence can be represented as a sequence with 4 characters. If a particular property of the DNA is studied, for example, GC content, then it is possible to consider a binary sequence. In many cases, if the probabilistic properties of a segment differ from the neighbouring ones, this means that the segment can play a structural(More)
6. W. E. Clendenning and R. B. Stoughton, J. Invest. Derm., 39, 47-49 (1969)o 7. C. W. Barrett, J. Soc. Cosmet. Chem., 20, 487-499 (1969). 8. K. C. James and M. Roberts, J. Pharm. Pharmacol., 20, 709-714 (1968). 9. K. C. James, P. J. Nicholls, and M. Roberts, J. Pharm. Pharmacol., 21, 24-27 (1969). i0. C. Hansch, A. R. Steward, et al., J. Med. Chem., ii,(More)
It is well-known that many genomes are highly structured. So determining domains of similar pattern is a very important area of bioinformatics research. This paper describes a Cross-Entropy algorithm for identifying change-points in four-letter DNA sequences. We propose a multiple change-point model for this problem and show effectiveness of our algorithm(More)