Tatiana V. Polushina

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Change-point problems (or break point problems, disorder problems) can be considered one of the central issues of statistics, connecting asymptotic statistical theory and Monte Carlo methods, frequentist and Bayesian approaches, fixed and sequential procedures. In many real applications, observations are taken sequentially over time, or can be ordered with(More)
Array comparative genomic hybridization (aCGH) is one of the techniques that can be used to detect copy number variations in DNA sequences in high resolution. It has been identified that abrupt changes in the human genome play a vital role in the progression and development of many complex diseases. In this study we propose two distinct hybrid algorithms(More)
A deoxyribonucleic acid (DNA) sequence can be represented as a sequence with 4 characters. If a particular property of the DNA is studied, for example, GC content, then it is possible to consider a binary sequence. In many cases, if the probabilistic properties of a segment differ from the neighbouring ones, this means that the segment can play a structural(More)