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Change-point problems (or break point problems, disorder problems) can be considered one of the central issues of statistics, connecting asymptotic statistical theory and Monte Carlo methods, frequentist and Bayesian approaches, fixed and sequential procedures. In many real applications, observations are taken sequentially over time, or can be ordered with… (More)

A deoxyribonucleic acid (DNA) sequence can be represented as a sequence with 4 characters. If a particular property of the DNA is studied, for example, GC content, then it is possible to consider a binary sequence. In many cases, if the probabilistic properties of a segment differ from the neighbouring ones, this means that the segment can play a structural… (More)

It is well-known that many genomes are highly structured. So determining domains of similar pattern is a very important area of bioinformatics research. This paper describes a Cross-Entropy algorithm for identifying change-points in four-letter DNA sequences. We propose a multiple change-point model for this problem and show effectiveness of our algorithm… (More)

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