Tatiana V. Karamysheva

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X inactivation, the transcriptional silencing of one of the two X chromosomes in female mammals, achieves dosage compensation of X-linked genes relative to XY males. In eutherian mammals X inactivation is regulated by the X-inactive specific transcript (Xist), a cis-acting non-coding RNA that triggers silencing of the chromosome from which it is(More)
In the present study, an analysis of the DNA homology of the pericentric chromosomal regions and pericentric heterochromatin in distantly related species of wood mice (species from the Apodemus genus, as well as from the Apodemus and Sylvaemus genera) was conducted by fluorescent in situ hybridization (FISH) of microdissected DNA probes obtained from the(More)
Repetitive DNA accounts for a significant part of the eukaryotic genome, forming large clusters or being relatively uniformly distributed through euchromatic chromosome regions. Repeats make it difficult to analyze and to identify chromosomal material by its DNA composition via fluorescence in situ hybridization (FISH). In most cases, signals from unique(More)
Currently, suppression of repetitive DNA sequences (chromosomal in situ suppression hybridization (CISS hybridization)) is used to improve the results of fluorescence in situ hybridization (FISH). However, sometimes the suppression cannot be performed due to insufficient amounts of DNA of some species. This paper presents a new approach that allows(More)
Korean field mouse (Apodemus peninsulae) is widely distributed throughout northeastern Asia, including the Russian Far East, northern China, the Korean Peninsula, Sakhalin, and Hokkaido. This mouse species is characterized by a high frequency of animals with B chromosomes differing in their number, morphology, and DNA composition in different geographical(More)
B chromosomes (Bs) are known for more than hundred years but their origin, structure and pattern of evolution are not well understood. In the past few years new methodological approaches, involving isolation of Bs followed by whole DNA amplification, DNA probe generation, and fluorescent in situ hybridization (FISH) or the B chromosome DNA sequencing, has(More)
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