Tatiana I Samoylova

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Screening with a 7-mer phage display peptide library, a panel of cell-targeting peptides for the murine microglial cell line, EOC 20, was recognized. A number of similar, but not identical, sets of sequences representing more than 75% of all the cell line-binding clones were identified. Comparative analysis indicated that motif S/(T) F T/(X) Y W is present(More)
Lysosomal beta-galactosidase is required for the degradation of GM1 ganglioside and other glycolipids and glycoproteins with a terminal galactose moiety. Deficiency of this enzyme leads to the lysosomal storage disorder, GM1 gangliosidosis, marked by severe neurodegeneration resulting in premature death. As a step towards preclinical studies for enzyme(More)
Glioblastomas are aggressive, lethal primary brain tumors that affect human and canine patients. A subpopulation representing a variably large percentage of the bulk of tumor cells has been identified to have stem cell-like properties based on expression of certain molecular markers and growth properties in specialized culture conditions. This cancer(More)
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