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—Software traceability is the ability to describe and follow the life of a requirement in both a forward and backward direction by defining relationships to related development arti-facts. A plethora of different traceability recovery approaches use information retrieval techniques, which depend on the quality of the textual information in requirements and(More)
The nonlinearities found in molecular networks usually prevent mathematical analysis of network behaviour, which has largely been studied by numerical simulation. This can lead to difficult problems of parameter determination. However, molecular networks give rise, through mass-action kinetics, to polynomial dynamical systems, whose steady states are zeros(More)
In the past decade, there have been many well-publicized cases of source code leaking from different well-known companies. These leaks pose a serious problem when the source code contains sensitive information encoded in its identifier names and comments. Unfortunately, redacting the sensitive information requires obfuscating the identifiers, which will(More)
Cytokine-hormone network deregulations underpin pathologies ranging from autoimmune disorders to cancer, but our understanding of these networks in physiological/pathophysiological states remains patchy. We employed Bayesian networks to analyze cytokine-hormone interactions in vivo using murine lactation as a dynamic, physiological model system. Circulatory(More)
Experimental and theoretical studies have suggested that bifunctional enzymes catalyzing opposing modification and demodification reactions can confer steady-state concentration robustness to their substrates. However, the types of robustness and the biochemical basis for them have remained elusive. Here we report a systematic study of the most general(More)
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