Tasos C. Christofides

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BACKGROUND Autosomal-dominant medullary cystic kidney disease (ADMCKD), a hereditary chronic interstitial nephropathy, recently attracted attention because of the cloning or mapping of certain gene loci, namely NPHP1, NPHP2 and NPHP3 for familial juvenile nephronophthisis (NPH) and MCKD1 and MCKD2 for the adult form of medullary cystic kidney disease. Our(More)
This study undertook an exploratory data analysis of the binding parameters of HIV-1 integrase inhibitors. The study group involved inhibitors in preclinical development from the diketo acid, pyrroloquinoline and naphthyridine carboxamide families and the most advanced inhibitors Raltegravir and Elvitegravir. Distinct differences were observed in the(More)
AIM The homozygous 677TT mutation of the MTHFR gene has been linked to deep vein thrombosis and to arterial atherosclerotic events of the coronary, carotid and peripheral arteries. Its putative association with renal arteriosclerosis and chronic renal failure (CRF) in the presence of hypertensive nephrosclerosis is yet to be investigated. METHODS Two(More)
In recent years, sensor networks characteristics have led to incremental utilization in different types of applications. Several techniques have been proposed to evaluate the performance of WSNs; the two most popular being mathematical analysis and simulations. An important drawback of these techniques is that they provide evaluation results that usually(More)
Demimartingales and demisubmartingales introduced by Newman and Wright (1982) generalize the notion of martingales and submartingales respectively. In this paper we define multidimensionally indexed demimartingales and demisubmartingales and prove a maximal inequality for this general class of random variables. As a corollary we obtain a Hájek-Rényi(More)
Let X1, X2, . . . and Y1, Y2, . . . be two sequences of absolutely continuous, independent and identically distributed (i.i.d.) randomvariableswith equalmeansE(Xi) = E(Yi), i = 1, 2, . . . . In this work we provide upper bounds for the total variation and Kolmogorov distances between the distributions of the partial sums ∑n i=1 Xi and ∑n i=1 Yi . In the(More)
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