Tasneem Kausar

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Proteins do not operate as individual units, and components of intracellular canonical pathways often cross talk in tumor genesis. We hypothesized that G-protein-coupled receptor 56 (GPR56), transglutaminase (TG2), and nuclear factor-κB (NF-κB) may collaborate in interconnected pathways and contribute to the aggressive behavior of esophageal squamous cell(More)
INTRODUCTION Esophageal adenocarcinomas (EAC) are aggressive cancers that are increasing in incidence and associated with a poor prognosis. The identification of highly expressed genes in EAC relative to metaplastic Barrett's esophagus (BE) may provide new targets for novel early cancer detection strategies using endoscopically administered, fluorescently(More)
Expression of sperm protein 17 (Sp17) mRNA has been reported in various malignancies. In an earlier study, we reported the upregulation of Sp17 transcripts in primary esophageal squamous cell carcinomas (ESCCs) using differential display and detected Sp17 transcripts in 86% of ESCCs by RT-PCR, whereas no transcripts were detected in the paired normal(More)
Expression of oncostatin M receptor beta (OSMRβ) has been reported in human cancers, however its role in esophageal squamous cell carcinoma (ESCC) remains unknown. Using differential display, earlier we reported the identification of an alternatively spliced variant of OSMRβ in ESCC. Here in we characterized this novel variant encoding a soluble form of(More)
We recently found 14-3-3 zeta to be overexpressed in esophageal squamous cell carcinomas (ESCCs) by differential display. In the present study we determined the clinical significance of 14-3-3 zeta in esophageal tumorigenesis. Immunohistochemical analysis was carried out in 61 ESCCs, 33 dysplasia samples, 14 hyperplasia samples and 7 matched histologically(More)
Aim: To investigate the obstetrical complications of grand-multiparity at a tertiary care hospital in Bahawalpur, Pakistan. Methods: This descriptive study was conducted at the Department of Obstetrics and Gynaecology, Bahawal Victoria Hospital Bahawalpur, Pakistan. A total of 500 un-booked and referred grand multiparous women (para 05 or above) were(More)
Aim: To evaluate the outcome between abdominal and vaginal hysterectomy in terms of mean operative time, hospital stay and complication rate. Methods: A total of 76 patients who had required hysterectomy for benign pathology with uterus of less than 14 weeks size, utero-vaginal prolapse or those with failed medical treatment in dysfunctional uterine(More)
1 Department of Biochemistry, All India Institute of Medical Science, New Delhi, India 2 Department of Surgery, University of Michigan, Ann Arbor, MI 3 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 4 Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada 5 Department of(More)
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