The mechanical properties of extracellular matrix (ECM) and connective tissues is largely dependent on the collagen and elastin structure. Lysyl oxidase (LOX) plays a critical role in the formation and repair of the ECM by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent cross linkages which stabilize these… (More)
An intramolecular dehydrogenative C-H activation enabled an efficient synthesis of an uracil-annulated β-carbolinone ring system. The reaction is simple, efficient and high yielding (85-92%).
Lipoprotein – X(abnormal lipoprotein) is rich in phospholipids and unesterified cholesterol. The main protein component is albumin within the core and apolipoprotein C upon the surface. It is cleared by the reticuloendothelial system and the kidneys. Earlier studies reported presence of lipoprotein X (LP-X) in patients with cholestasis. Bile lipoprotein is… (More)