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An intramolecular dehydrogenative C-H activation enabled an efficient synthesis of an uracil-annulated β-carbolinone ring system. The reaction is simple, efficient and high yielding (85-92%).
Lipoprotein – X(abnormal lipoprotein) is rich in phospholipids and unesterified cholesterol. The main protein component is albumin within the core and apolipoprotein C upon the surface. It is cleared by the reticuloendothelial system and the kidneys. Earlier studies reported presence of lipoprotein X (LP-X) in patients with cholestasis. Bile lipoprotein is… (More)
The mechanical properties of extracellular matrix (ECM) and connective tissues is largely dependent on the collagen and elastin structure. Lysyl oxidase (LOX) plays a critical role in the formation and repair of the ECM by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent cross linkages which stabilize these… (More)