Tarrek Hassanin

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We present a case of fatal, progressive hepatotoxicity in a patient treated with lamotrigine. After presenting with a rash and fever, she developed elevated liver function tests and clinical sequelae of hepatic failure. The subacute course of her progressive liver damage is documented in serial liver biopsies. While her initial biopsy showed approximately(More)
Lamotrigine is a relatively new antiepileptic drug that blocks voltage-sensitive sodium channels in order to inhibit the release of excitatory amino acids and to stabilize neuromembranes (1). This reduces the levels of glutamate, an excitatory amino acid that is associated with seizure activity (2). The most commonly reported side effects include nausea,(More)
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