Tarou Nakamura

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Cilnidipine is an L/N-type calcium channel blocker (CCB). The effects of cilnidipine on N-type channels give it unique organ-protective properties via the suppression of hyperactivity in the sympathetic nervous system (SNS) and renin-angiotensin-aldosterone system (RAAS). In the present study, we compared the effects of cilnidipine and amlodipine (an L-type(More)
Cilnidipine (Cil), which is an L-/N-type calcium channel blocker (CCB), has been known to provide renal protection by decreasing the activity of the sympathetic nervous system (SNS) and the renin-angiotensin system. In this study, we compared the effects of the combination of Cil and amlodipine (Aml), which is an L-type CCB, with an angiotensin (Ang) II(More)
The current through a myocardial inward rectifier K+ channel was recorded by the patch clamp technique. The inactivation gate of the channel has open probability of nearly 1 at the potentials positive to EK and showed peculiar kinetics in the 1st open events after hyperpolarization from these potentials. Analysis of this kinetics suggested two open states(More)
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