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We developed an implantable one-chip biofluoroimaging device (termed biomedical photonic LSI; BpLSI) which enabled real-time molecular imaging with conventional electrophysiology in vivo in deep brain areas. The multimodal LSI enabled long-term sequential imaging of the fluorescence emitted by proteolysis-linked fluorogenic substrate. Using the BpLSI, we(More)
Previously, we reported a new neural imaging approach based on a CMOS imaging device. Using the device, we demonstrated real-time in vivo protease imaging inside the mouse hippocampus. In this work, we explore MEMS microfabrication technologies to develop a next generation device. By embedding electrodes onto the sensor chip and improving the packaging(More)
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