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Intranigral injection of muscimol induced hyperactivity in rats and antagonized haloperidol-induced catalepsy. Intranigral injection of gabaculine, an inhibitor of GABA transaminase, induced similar effects 5h after injection, when the nigral GABA content was increased 7-fold. On the other hand, injections of muscimol (30 ng) into the globus pallidus(More)
The use of Big Data can hold considerable benefits for organizations, but there is as yet little research on the impacts of Big Data use on key variables such as competitive advantage. The antecedents to Big Data use aiming at competitive advantage are also poorly understood. Drawing from prior research on the ICT-competitiveness link, this research(More)
Two years after the Great Eastern Japan Earthquake Disaster that occurred on March 11 on 2011, and the subsequent nuclear plant failure at Fukushima, organizations are rethinking their business continuity plans to accommodate large-scale crises. Yet Information Technology (IT) functions may benefit from lessons other than the technical or procedural. People(More)
Independent site administration is not as easy for small-sized companies as it is for large ones in the field of B2C e-commerce from the perspective of limited resources. The most prevalent and effective method of compensating for such limited resources is through participation in organizations such as intermediary sites like online shopping malls. On the(More)
10-Bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one (CS-430) is a new psychotropic drug and has the following properties. The compound showed sleep-inducing effect at both 0.2 and 5 mg/kg (p.o.) in cynomolgus monkeys or at 3 mg/kg (p.o.) in rats. CS-430 showed selective conflict attenuating in rats or anticonvulsant(More)
Gabaculine, a specific inhibitor of GABA transaminase, was injected bilaterally into the substantia nigra of rats. One day after injection, GABA was increased 11-fold in the nigra, 6-fold in thalamus and pons-medulla, and 2-fold in pallidum. 5 h after operation, rats showed continuous sniffing and head movement. This behaviour was blocked by a small dose of(More)
This experiment was conducted to examine effects of oxazolam, cloxazolam, CS-386, and reference drugs on socially induced suppression and aggression in pairs of monkeys. Oxazolam, cloxazolam, and CS-386, as well as other benzodiazepines, at both ataxic and non-ataxic doses, attenuated the socially induced suppression, but failed to show inhibitory effect on(More)