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We examined the relationship of age-related losses of striatal dopamine transporter (DAT) density to age-related deficits in episodic memory and executive functioning in a group of subjects (n = 12) ranging from 34 to 81 years of age. The radioligand [(11)C]beta-CIT-FE was used to determine DAT binding in caudate and putamen. Results showed clear(More)
The present study tests the hypothesis that the dopamine system is altered in idiopathic generalized epilepsy (IGE), and that the pattern of possible changes differs between juvenile myoclonic epilepsy (JME) and epilepsy with tonic-clonic seizures only (GTCS). The dopamine (DA) system was investigated with PET and a DA transporter (DAT) ligand [(11)C]PE2I(More)
The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors (n=45) from a previously published cross-sectional study. Participants were aged 75-93 years at baseline,(More)
The aim of the present study was to investigate verbal fluency in preclinical Huntington's disease (HD). Phonemic and semantic fluency and the rate of word production over time were assessed for 29 asymptomatic gene carriers and 34 noncarriers of HD. The relationship between fluency tasks and other cognitive domains was investigated. Compared to(More)
OBJECTIVE The aims of this study were to investigate the relationships between performance on the National Adult Reading Test (NART) and retrospective, concurrent, and prospective memory functioning, as well as between the NART and change in memory functioning over time. METHOD NART administered in 2005 was used as a predictor for memory functioning in(More)
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