Tarek S. Makram

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Coevaporates of warfarin sodium containing different weight fractions of polyvinylpyrrolidone (Kollidon s5 and 30) polymers of different molecular weights were prepared and their characterization, dissolution properties as well as their bioavailability in rabbits were assessed. UV and IR spectrophotometery revealed a sort of binding between the drug and(More)
CONTEXT Ketorolac is one of the most potent nonsteroidal anti-inflammatory drugs and is an attractive alternative to opioids for pain management. OBJECTIVE Development and evaluation of transdermal ketorolac film forming polymeric solution. MATERIALS AND METHODS Eudragits(®) RLPO, RSPO and E100 as well as polyvinyl pyrrolidone K30 dissolved in ethanol(More)
The interaction of warfarin and dicumarol with methyl xanthines was monitored. The results revealed formation of equimolar complexes with both caffeine and theophylline. The interaction is exothermic and complexation is thermodynamically unfavourable. The apparent solubility of dicumarol in water was found to increase linearly with increasing methyl(More)
The effect of inclusion complexation of furosemide in cyclodextrins (CyD) on the bioavailability of the drug was studied on normal human volunteers. The excretion rate of the drug was determined by HPLC for a period of 24 h. post dosing. Several pharmacokinetic parameters were calculated and statistically analyzed. viz., peak excretion rate, peak excretion(More)
BACKGROUND Fenoprofen calcium dehydrate (FCD) is counted as a non-steroidal, anti-inflammatory, anti-arthritic drug. FCD is slightly water soluble. It is indicated for mild pain relief, where the suggested dosage is 200 mg orally every 4 to 6 h. AIM Reduce dissolution efficiency, reach an extended therapeutic effect and reduce the frequency of the drug(More)
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