Tara McDonnell

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This investigation characterizes the atrial proliferative response following partial ventricular amputation in adult newts. Newts processed for light microscopic autoradiography were given either a single injection (SI) of 3H-thymidine 1 hr before fixation and killed at intervals up to 25 days after ventricular wounding or were given six injections (MU),(More)
The delivery systems of two long-acting formulations of methylphenidate (MPH) were designed for different durations. Diffucaps bead-delivery system (DBDS)-MPH was designed to last 8 h and osmotically controlled-release oral delivery system (OROS)-MPH was designed to last 12 h. While the plasma pharmacokinetics and timing of efficacy have been studied, the(More)
This report describes a technique which permits a high yield of viable adult cardiac myocytes from the adult newt using enzymatic separation techniques at low temperature and high enzyme concentrations. Observations by light microscopy showed the isolated myocytes to have a distinctively slender morphology which consisted of a variable number of arm-like(More)
The patterns of lung eicosanoid production were investigated in five different species by stimulating isolated lungs with calcium ionophore A23187 (10(-5) M). The species studied were the rat, ferret, hamster, guinea pig, and rabbit. The eicosanoids measured included the cyclooxygenase metabolites 6-keto-PGF1 alpha, TxB2, and PGE2 and the lipoxygenase(More)
The role of leukotrienes in the mechanism of hypoxic pulmonary vasoconstriction (HPV) is controversial. To determine whether leukotriene C4 (LTC4) was produced during HPV, LTC4 levels were measured in individual samples of lung tissue, lung bronchoalveolar lavage fluid (BALF), and blood perfusate in isolated perfused lungs ventilated with normoxic or(More)
Administration of the antifungal antibiotic amphotericin B (AmB, 1 mg/kg) to intact rats produced acute lung injury as indicated by the extravascular leakage of protein and water and histological examination. The injury was neutrophil independent because it occurred in neutropenic rats. AmB produced vasoconstriction and injury in isolated lungs perfused(More)
Alveolar transfer of eicosanoids was studied in the rat after instillation of [3H] prostaglandins, leukotrienes, and arachidonate into the distal airways. The percentage of originally added label remaining in lung or lavage was determined 2 min after instillation, with the remainder of the label having been transferred out of the lung. Peptidoleukotrienes(More)
ARDS is a relatively common disorder whose high mortality has changed little over the past few years. Management remains supportive in essence, consisting of careful ventilatory management and attention to fluid balance and nutritional needs. Certain complications, especially sepsis, need to be prevented if possible. Currently, there is no pharmacologic(More)
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