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The development of microwave breast cancer detection and treatment techniques has been driven by reports of substantial contrast in the dielectric properties of malignant and normal breast tissues. However, definitive knowledge of the dielectric properties of normal and diseased breast tissues at microwave frequencies has been limited by gaps and(More)
The paper describes a computerized method, termed receptive field imaging (RFI), for the rapid mapping of multiple receptive fields and their respective sensitivity distributions. RFI uses random stimulation of multiple sites, in combination with an averaging procedure, to extract the relative contribution from each of the stimulated sites. Automated(More)
BACKGROUND For patients with potentially resectable pancreatic cancer, the poor outcome associated with resection alone and the survival advantage demonstrated for combined-modality therapy have stimulated interest in preoperative chemoradiotherapy. The goal of this study was to analyze the effects of different preoperative chemoradiotherapy schedules,(More)
Nonmalignant (n = 36) and malignant (n = 20) tissue samples were obtained from breast cancer and breast reduction surgeries. These tissues were characterized using multiple excitation wavelength fluorescence spectroscopy and diffuse reflectance spectroscopy in the ultraviolet-visible wavelength range, immediately after excision. Spectra were then analyzed(More)
The fluorescence of tryptophan, reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and flavin adenine dinucleotide (FAD) were characterized in normal human breast cells as well as in malignant human breast cells of similar and dissimilar genetic origins. Fluorescence measurements of each cell line were made over a wide range of cell(More)
BACKGROUND Fluorescence spectroscopy is an evolving technology that can rapidly differentiate between benign and malignant tissues. These differences are thought to be due to endogenous fluorophores, including nicotinamide adenine dinucleotide, flavin adenine dinucleotide, and tryptophan, and absorbers such as beta-carotene and hemoglobin. We hypothesized(More)
We explored the use of diffuse reflectance spectroscopy in the ultraviolet-visible (UV-VIS) spectrum for the diagnosis of epithelial pre-cancers and cancers in vivo. A physical model (Monte Carlo inverse model) and an empirical model (principal component analysis, (PCA)) based approach were compared for extracting diagnostic features from diffuse(More)
  • F Abdat, M Amouroux, Y Guermeur, W Blondel, T C M Zhu, J Breslin +95 others
  • 2011
This paper deals with multi-class classification of skin pre-cancerous stages based on bimodal spectroscopic features combining spatially resolved AutoFluorescence (AF) and Diffuse Reflectance (DR) measurements. A new hybrid method to extract and select features is presented. It is based on Discrete Cosine Transform (DCT) applied to AF spectra and on Mutual(More)
signatures in human cancers as a guide to targeted therapies. diffuse reflectance properties of malignant and benign breast tissues. Improvement in breast tumor discrimination by support vector machines and speckle-emphasis texture analysis. Automatic ultrasound segmentation and morphology based diagnosis of solid breast tumors.resolution aCGH and(More)
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