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The effects of HSP27 on human monocytes (MO) are predominantly antiinflammatory through preferential interleukin (IL)10 induction and by alteration of MO to immature dendritic cells (iDCs) or MO to macrophage (Mac) differentiation. Initial HSP27 inclusion in IL4+GM-CSF MO to iDC induction cultures allows Mac differentiation (CD14++, CD16+), decreases iDC(More)
T. Herrmann,1 I. A. Dmitriev,2,3 D. A. Kozlov,4,5 M. Schneider,1 B. Jentzsch,1 Z. D. Kvon,4,5 P. Olbrich,1 V. V. Bel’kov,3 A. Bayer,1 D. Schuh,1 D. Bougeard,1 T. Kuczmik,1 M. Oltscher,1 D. Weiss,1 and S. D. Ganichev1 1Terahertz Center, University of Regensburg, 93040 Regensburg, Germany 2Max Planck Institute, 70569 Stuttgart, Germany 3Ioffe Institute,(More)
Advances in understanding of the immune system are changing the way oncologists treat cancer. In recent years, researchers have increasingly looked to harnessing the patient's immune system in the management of difficult to treat cancers. While such an approach was once felt to be unattainable, a better understanding of how the adaptive immune system works(More)