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In experimental autoimmune neuritis (EAN), T-cell receptor (TCR) variable (V)-region gene usage by neuritogenic T cells has been reported to be clonally restricted at the RNA level. This study was designed to verify TCR usage by neuritogenic T cells at the protein level. We generated two monoclonal antibodies (mAbs) 7H4 and 8G8 specific for a(More)
Advances in understanding of the immune system are changing the way oncologists treat cancer. In recent years, researchers have increasingly looked to harnessing the patient's immune system in the management of difficult to treat cancers. While such an approach was once felt to be unattainable, a better understanding of how the adaptive immune system works(More)
T-cell receptor (TCR) beta-chain usage in experimental autoimmune encephalomyelitis (EAE) seems to be much more heterogeneous than previously assumed even for a single autoantigen in an inbred animal strain. Owing to the lack of suitable antibodies, this has been demonstrated only at the RNA level so far. To characterize further the TCR elements used in the(More)
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