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The effects of HSP27 on human monocytes (MO) are predominantly antiinflammatory through preferential interleukin (IL)10 induction and by alteration of MO to immature dendritic cells (iDCs) or MO to macrophage (Mac) differentiation. Initial HSP27 inclusion in IL4+GM-CSF MO to iDC induction cultures allows Mac differentiation (CD14++, CD16+), decreases iDC(More)
Advances in understanding of the immune system are changing the way oncologists treat cancer. In recent years, researchers have increasingly looked to harnessing the patient's immune system in the management of difficult to treat cancers. While such an approach was once felt to be unattainable, a better understanding of how the adaptive immune system works(More)
INTRODUCTION The Affordable Care Act is moving medical care-and medical education-toward a quality-driven environment. Quality medical education must be available when the health care provider is ready to learn, provide feedback, and maximize translation of knowledge from desk to clinic. To best accomplish these goals, medical education must be personalized(More)
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