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- Publications
- Influence
Calreticulin enhances porcine wound repair by diverse biological effects.
- L. Nanney, C. Woodrell, +8 authors L. Gold
- Biology, Medicine
- The American journal of pathology
- 1 September 2008
Extracellular functions of the endoplasmic reticulum chaperone protein calreticulin (CRT) are emerging. Here we show novel roles for exogenous CRT in both cutaneous wound healing and diverse… Expand
A dominant negative Cx43 mutant differentially affects tumorigenic and invasive properties in human metastatic melanoma cells
- S. N. Zucker, Tara A Bancroft, David E Place, Benjamin Des Soye, A. Bagati, R. Berezney
- Biology, Medicine
- Journal of cellular physiology
- 1 April 2013
Previous reports have implicated connexin 43 (Cx43) as a tumor suppressor in early stages of tumorigenesis and in some cases as an enhancer of cell migration in later stages. To address the role of… Expand
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
- M. Lee, Amelia K. Luciano, +7 authors W. Sessa
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 18 August 2014
Significance The expression of multiple isoforms of a protein kinase in cells raises the question of which substrates are preferentially phosphorylated by each isoform. Endothelial cells (ECs) that… Expand
Exogenous calreticulin improves diabetic wound healing
- M. Greives, F. Samra, +9 authors L. Gold
- Biology, Medicine
- Wound repair and regeneration : official…
- 1 September 2012
A serious consequence of diabetes mellitus is impaired wound healing, which largely resists treatment. We previously reported that topical application of calreticulin (CRT), an endoplasmic reticulum… Expand
HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.
- Susan MacLauchlan, N. E. Calabro, +7 authors T. Kyriakides
- Biology, Medicine
- Matrix biology : journal of the International…
- 5 August 2017
Thrombospondin-2 (TSP2) is a potent inhibitor of angiogenesis whose expression is dynamically regulated following injury. In the present study, it is shown that HIF-1α represses TSP2 transcription.… Expand
Up-regulation of Thrombospondin-2 in Akt1-null Mice Contributes to Compromised Tissue Repair Due to Abnormalities in Fibroblast Function*
- Tara A Bancroft, Mohamed Bouaouina, +6 authors T. Kyriakides
- Biology, Medicine
- The Journal of Biological Chemistry
- 11 November 2014
Background: TSP2 and Akt1 exert opposite effects on tissue repair. Results: Akt1 KO mice display defects in fibroblast morphology and adhesion due to diminished Rac activation, which is a result of… Expand
Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes
- Britta Kunkemoeller, Tara A Bancroft, +5 authors T. Kyriakides
- Medicine
- Diabetes
- 6 August 2019
Impaired wound healing is a major complication of diabetes, and despite the associated risks, treatment strategies for diabetic wounds remain limited. This is due, in part, to an incomplete… Expand