• Publications
  • Influence
Calreticulin enhances porcine wound repair by diverse biological effects.
Extracellular functions of the endoplasmic reticulum chaperone protein calreticulin (CRT) are emerging. Here we show novel roles for exogenous CRT in both cutaneous wound healing and diverseExpand
  • 90
  • 4
  • PDF
A dominant negative Cx43 mutant differentially affects tumorigenic and invasive properties in human metastatic melanoma cells
Previous reports have implicated connexin 43 (Cx43) as a tumor suppressor in early stages of tumorigenesis and in some cases as an enhancer of cell migration in later stages. To address the role ofExpand
  • 20
  • 2
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
Significance The expression of multiple isoforms of a protein kinase in cells raises the question of which substrates are preferentially phosphorylated by each isoform. Endothelial cells (ECs) thatExpand
  • 85
  • 1
  • PDF
Exogenous calreticulin improves diabetic wound healing
A serious consequence of diabetes mellitus is impaired wound healing, which largely resists treatment. We previously reported that topical application of calreticulin (CRT), an endoplasmic reticulumExpand
  • 23
  • 1
  • PDF
HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.
Thrombospondin-2 (TSP2) is a potent inhibitor of angiogenesis whose expression is dynamically regulated following injury. In the present study, it is shown that HIF-1α represses TSP2 transcription.Expand
  • 14
  • 1
Up-regulation of Thrombospondin-2 in Akt1-null Mice Contributes to Compromised Tissue Repair Due to Abnormalities in Fibroblast Function*
Background: TSP2 and Akt1 exert opposite effects on tissue repair. Results: Akt1 KO mice display defects in fibroblast morphology and adhesion due to diminished Rac activation, which is a result ofExpand
  • 9
  • PDF
Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes
Impaired wound healing is a major complication of diabetes, and despite the associated risks, treatment strategies for diabetic wounds remain limited. This is due, in part, to an incompleteExpand
  • 4