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Genomic profiling identifies alterations in TGFβ signaling through loss of TGFβ receptor expression in human renal cell carcinogenesis and progression
Renal cell carcinoma (RCC) is a major health issue. Whereas localized disease can be cured surgically, there is no effective therapy for metastatic disease. The development of an effective therapyExpand
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Phase 2 trial of neoadjuvant axitinib in patients with locally advanced nonmetastatic clear cell renal cell carcinoma.
BACKGROUND Previous studies have shown a modest impact of tyrosine kinase inhibitors on primary renal tumors. Those studies were mostly retrospective or heterogeneous in their eligibility criteriaExpand
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Type III Transforming Growth Factor-β (TGF-β) Receptor Mediates Apoptosis in Renal Cell Carcinoma Independent of the Canonical TGF-β Signaling Pathway
Purpose: Alterations in transforming growth factor-β (TGF-β) signaling occur early during malignant transformation of renal epithelial cells and are associated with loss of type III TGF-β receptorExpand
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Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Purpose: Sunitinib is currently considered as the standard treatment for advanced renal cell carcinoma (RCC). We aimed to better understand the mechanisms of sunitinib action in kidney cancerExpand
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  • Open Access
NICOTINAMIDE N-METHYLTRANSFERASE OVEREXPRESSION IS ASSOCIATED WITH AN AGGRESSIVE BIOLOGIC PHENOTYPE AND CHEMORESISTANCE IN CLEAR CELL RENAL CELL CARCINOMA
INTRODUCTION AND OBJECTIVE: Previous studies have shown that expression of nicotinamide N-methyltransferase (NNMT) is increased in clear cell renal cell carcinoma (cRCC). We sought to confirm theseExpand
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The role of ZNF395 in renal cell carcinoma proliferation, migration, and invasion.
592 Background: Zinc finger protein 395 (ZNF395) is frequently altered in several tumor types. However, the role of ZNF395 remains poorly studied in patients with clear cell renal cell carcinomaExpand
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Origin of somatic transformation in germ cell tumor of testis (TGCT): Role of differentiation versus dedifferentiation in a mature teratoma.
410Background: TGCT is a prototype stem-cell malignancy recapitulating the ontogeny of solid tumors. We studied the roles of differentiation versus dedifferentiation in a bona fide well-differentia...
Cancer Therapy : Preclinical Autotaxin – Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Purpose: Sunitinib is currently considered as the standard treatment for advanced renal cell carcinoma (RCC).Weaimed tobetter understand themechanismsof sunitinib action inkidney cancer treatment andExpand