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Genomic profiling identifies alterations in TGFβ signaling through loss of TGFβ receptor expression in human renal cell carcinogenesis and progression
Renal cell carcinoma (RCC) is a major health issue. Whereas localized disease can be cured surgically, there is no effective therapy for metastatic disease. The development of an effective therapy… Expand
Phase 2 trial of neoadjuvant axitinib in patients with locally advanced nonmetastatic clear cell renal cell carcinoma.
BACKGROUND Previous studies have shown a modest impact of tyrosine kinase inhibitors on primary renal tumors. Those studies were mostly retrospective or heterogeneous in their eligibility criteria… Expand
Type III Transforming Growth Factor-β (TGF-β) Receptor Mediates Apoptosis in Renal Cell Carcinoma Independent of the Canonical TGF-β Signaling Pathway
- V. Margulis, Tapati Maity, X. Zhang, S. Cooper, J. Copland, C. Wood
- Biology, Medicine
- Clinical Cancer Research
- 15 September 2008
Purpose: Alterations in transforming growth factor-β (TGF-β) signaling occur early during malignant transformation of renal epithelial cells and are associated with loss of type III TGF-β receptor… Expand
Autotaxin–Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
- Shih-Chi Su, Xiaoxiao Hu, +7 authors C. Wood
- Medicine, Biology
- Clinical Cancer Research
- 11 October 2013
Purpose: Sunitinib is currently considered as the standard treatment for advanced renal cell carcinoma (RCC). We aimed to better understand the mechanisms of sunitinib action in kidney cancer… Expand
NICOTINAMIDE N-METHYLTRANSFERASE OVEREXPRESSION IS ASSOCIATED WITH AN AGGRESSIVE BIOLOGIC PHENOTYPE AND CHEMORESISTANCE IN CLEAR CELL RENAL CELL CARCINOMA
INTRODUCTION AND OBJECTIVE: Previous studies have shown that expression of nicotinamide N-methyltransferase (NNMT) is increased in clear cell renal cell carcinoma (cRCC). We sought to confirm these… Expand
The role of ZNF395 in renal cell carcinoma proliferation, migration, and invasion.
592 Background: Zinc finger protein 395 (ZNF395) is frequently altered in several tumor types. However, the role of ZNF395 remains poorly studied in patients with clear cell renal cell carcinoma… Expand
MP57-13 PHASE II TRIAL OF NEOADJUVANT AXITINIB IN PATIENTS WITH LOCALLY ADVANCED NON-METASTATIC CLEAR CELL RENAL CELL CARCINOMA
Origin of somatic transformation in germ cell tumor of testis (TGCT): Role of differentiation versus dedifferentiation in a mature teratoma.
410Background: TGCT is a prototype stem-cell malignancy recapitulating the ontogeny of solid tumors. We studied the roles of differentiation versus dedifferentiation in a bona fide well-differentia...
Cancer Therapy : Preclinical Autotaxin – Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma
Purpose: Sunitinib is currently considered as the standard treatment for advanced renal cell carcinoma (RCC).Weaimed tobetter understand themechanismsof sunitinib action inkidney cancer treatment and… Expand