Learn More
BACKGROUND The role of HBV X protein (HBx) in the development of hepatocellular carcinoma (HCC) has been well studied. However, little is known about the molecular functions of HBV whole-X protein (HBwx), a protein fused with HBx and upstream 56 amino acid, in HCC. In current study, the molecular functions of HBwx in HCC pathogenesis has been investigated,(More)
BACKGROUND In China, women with chronic HBV infection and who are of childbearing age receive lamivudine at an early age. Thus, viral resistance becomes a challenge for intervention to prevent mother-to-infant transmission. We prospectively assessed the efficacy of tenofovir in pregnant women with lamivudine-resistant HBV. METHODS Chronic HBV-infected(More)
The C-terminal domain (CTD) of hepadnavirus core protein is involved in multiple steps of viral replication. In particular, the CTD is initially phosphorylated at multiple sites to facilitate viral RNA packaging into immature nucleocapsids (NCs) and the early stage of viral DNA synthesis. For the avian hepadnavirus duck hepatitis B virus (DHBV), CTD is(More)
This paper presents a design and implementation of a low noise phase-locked loop (PLL) based on ring oscillator to provide timing clocks for the analog-to-digital converter (ADC). The ring oscillator consists of four current control delay cells with current-steering amplifier (CSA) circuit. These fully switching differential delay cells are employed to(More)
BACKGROUND AND AIM The efficacy of telbivudine for breaking vertical transmission of hepatitis B virus has been well established. Data on the risk of postpartum flare after telbivudine withdrawal and efficacy of extended antiviral therapy after delivery are limited. METHODS Chronic hepatitis B virus-infected women who received telbivudine beginning at(More)
BACKGROUND & AIMS We previously found that hepatic stellate cell activation induced by autophagy maintains the liver architecture to prevent collapse during acute liver failure. Nitric oxide has shown to induce hepatic stellate cell apoptosis. Whether and how nitric oxide is involved in acute liver failure and autophagy remains unclear. METHODS Acute(More)
A single-in-differential-out variable gain wideband LNA without on-chip inductor for CMMB TV tuner is implemented in 0.18 µm CMOS. The LNA provide gain modes ranging from 18 dB to −12 dB with a 6dB step. The LNA exhibits an IIP3 of 7.76 dBm and an NF of less than 2.4 dB at 18 dB gain mode. The output imbalance is only 0.01 dB in amplitude and(More)
BACKGROUND No or low hepatitis B (HB) vaccine response is more frequent in infants from HBsAg(+) mothers than those from HBsAg(-). Our previous study found temporary positivity of HBsAg in infants from HBsAg(+) mothers. In this study, we hypothesized that HBsAg in infant blunt immune response to standard hepatitis B vaccination. METHODS A total of 328(More)
The effect of hepatitis B immunoglobulin (HBIG) on hepatitis B virus (HBV) DNA load and its protective mechanism are not well understood. Twenty-eight hepatitis B surface antigen (HBsAg)-positive pregnant women and their newborns were assigned to an experimental (n = 12) or control group (n = 16) according to whether they received HBIG during pregnancy. HBV(More)