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Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identification and isolation of SC from normal and(More)
A new approach to tracking using active contours is presented. The class of objects to be tracked is assumed to be characterized by a probability distribution over some variable, such as intensity, color, or texture. The goal of the algorithm is to find the region within the current image, such that the sample distribution of the interior of the region most(More)
Interactive or semi-automatic segmentation is a useful alternative to pure automatic segmentation in many applications. While automatic segmentation can be very challenging, a small amount of user input can often resolve ambiguous decisions on the part of the algorithm. In this work, we devise a graph cut algorithm for interactive segmentation which(More)
This paper proposes a new density matching method based on background mismatching for tracking of nonrigid moving objects. The new tracking method extends the idea behind the original density-matching tracker, which tracks an object by finding a contour in which the photometric density sampled from the enclosed region most closely matches a model density.(More)
The ventral intraparietal area (VIP) is a multimodal parietal area, where visual responses are brisk, directional, and typically selective for complex optic flow patterns. VIP thus could provide signals useful for visual estimation of heading (self-motion direction). A central problem in heading estimation is how observers compensate for eye velocity, which(More)
In this paper, a steganographic algorithm in MPEG compressed video stream was proposed. In each GOP, the control information for to facilitate data extraction was embedded in I frame, in P frames and B frames, the actually transmitted data were repeatedly embedded in motion vectors of macro-blocks that have larger moving speed, for to resist video(More)
Autophagy is an important intracellular catabolic mechanism that mediates the degradation of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of autophagy named "spautin-1" for specific and potent autophagy inhibitor-1. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific(More)
We report the discovery and characterization of SM-406 (compound 2), a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). This compound binds to XIAP, cIAP1, and cIAP2 proteins with K(i) of 66.4, 1.9, and 5.1 nM, respectively. Compound 2 effectively antagonizes XIAP BIR3 protein in a cell-free(More)