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The MapReduce model is becoming prominent for the large-scale data analysis in the cloud. In this paper, we present the benchmarking, evaluation and characterization of Hadoop, an open-source implementation of MapReduce. We first introduce HiBench, a new benchmark suite for Hadoop. It consists of a set of Hadoop programs, including both synthetic(More)
The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer's disease (LOAD), we constructed gene-regulatory networks in 1,647 postmortem brain(More)
Gastric cancer is a heterogeneous disease with diverse molecular and histological subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with DNA copy number, gene expression and methylation profiling, for integrative genomic analysis. We found subtype-specific genetic and epigenetic perturbations and unique mutational signatures.(More)
Achieving high structural coverage such as branch coverage in object-oriented programs is an important and yet challenging goal due to two main challenges. First, some branches involve complex program logics and generating tests to cover them requires deep knowledge of the program structure and semantics. Second, covering some branches requires special(More)
XACML has become the de facto standard for specifying access control policies for various applications, especially web services. With the explosive growth of web applications deployed on the Internet, XACML policies grow rapidly in size and complexity, which leads to longer request processing time. This paper concerns the performance of request processing,(More)
A bug-tracking system such as Bugzilla contains bug reports (BRs) collected from various sources such as development teams, testing teams, and end users. When bug reporters submit bug reports to a bug-tracking system, the bug reporters need to label the bug reports as security bug reports (SBRs) or not, to indicate whether the involved bugs are security(More)
Most prior research on policies has focused on correctness. While correctness is an important issue, the adoption of policy-based computing may be limited if the resulting systems are not implemented efficiently and thus perform poorly. To increase the effectiveness and adoption of policy-based computing, in this paper, we propose fast policy evaluation(More)
Gnas is an imprinted gene with multiple gene products resulting from alternative splicing of different first exons onto a common exon 2. These products include stimulatory G protein alpha-subunit (G(s)alpha), the G protein required for receptor-stimulated cAMP production; extralarge G(s)alpha (XLalphas), a paternally expressed G(s)alpha isoform; and(More)
Access control policies are increasingly written in speci- fication languages such as XACML. To increase confidence in the correctness of specified policies, policy developers can conduct policy testing with some typical test inputs (in the form of requests) and check test outputs (in the form of responses) against expected ones. Unfortunately, manual test(More)