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Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.
Phototransduction and retinal degeneration in Drosophila
Drosophila visual transduction appears to have particular relevance to the cascade in the intrinsically photosensitive retinal ganglion cells in mammals, as the photoresponse in these latter cells appears to operate through a remarkably similar mechanism.
A Drosophila model for LRRK2-linked parkinsonism
- Zhaohui Liu, Xiaoyue Wang, Wanli W. Smith
- Biology, PsychologyProceedings of the National Academy of Sciences
- 19 February 2008
This is the first in vivo“gain-of-function” model which recapitulates several key features of LRRK2-linked human parkinsonism and may provide a useful model for studying L RRK 2-linked pathogenesis and for future therapeutic screens for PD intervention.
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme
- Tao Wang, Xiangbin Zhang, Poonam Bheda, Javier R. Revollo, S. Imai, C. Wolberger
- Biology, ChemistryNature Structural &Molecular Biology
- 18 June 2006
The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism*
ENampt protects macrophages from ER stress-induced apoptosis by activating an IL-6/STAT3 signaling pathway via a nonenzymatic mechanism, which suggests a novel action and mechanism of eNamPT that could affect the balance of macrophage survival and death in the setting of obesity, which in turn could play important roles in obesity-associated diseases.
Requirement for an Enzymatic Visual Cycle in Drosophila
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.
It is shown that both intracellular and extracellular NAMPT levels are increased in cells and plasma of chronic lymphocytic leukemia (CLL) patients, revealing that eNAMPT is a critical element in the induction of an immunosuppressive and tumor-promoting microenvironment of CLL.
The mechanism of OTUB1 inhibition of ubiquitination
Structural and biochemical studies elucidating how OTUB1 inhibits UBC13 and other E2 enzymes in a non-catalytic manner are described, and free ubiquitin is unexpectedly found to be allosterically regulated by free Ubiquitin.
Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction
A class B scavenger receptor is identified that functions upstream of vitamin A formation in neurons and glia, which are outside of the retina, and a pathway involving multiple extraretinal cell types and proteins essential for the formation of rhodopsin is proposed.