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Polarized epithelial membrane traffic: conservation and plasticity
TLDR
A pre-eminent challenge now is to understand the plasticity of polarized traffic, how it is altered by differentiation and dedifferentiation during development, as well as the adaptation of differentiated cells to meet changing physiological needs. Expand
A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor
TLDR
The results reveal a novel Yes–EGFR–ERK–FIP5 signalling network for regulation of pIgA–pIgR transcytosis and find that the Rab11 effector Rab11-FIP 5 is a substrate of ERK. Expand
Diuresis and reduced urinary osmolality in rats produced by small‐molecule UT‐A‐selective urea transport inhibitors
TLDR
It is found that intravenous administration of an indole thiazole or a γ‐sultambenzosulfonamide at 20 mg/kg increased urine output by 3‐5‐fold and reduced urine osmolality by ~ 2‐fold compared to vehicle control rats, even under conditions of maximum antidiuresis produced by 1‐deamino‐8‐D‐arginine vasopressin (DDAVP). Expand
Identification and functional analysis of ligands for natural killer cell activating receptors in colon carcinoma.
TLDR
expression of DNAM-1 and NKG2D was reduced in NK cells of colon cancer patients, and this reduction could directly suppress the activation of NK cells, ultimately leading to the inhibition of NK cytotoxicity. Expand
Clobetasol promotes remyelination in a mouse model of neuromyelitis optica
TLDR
Proof-of-concept for the potential utility of a remyelinating approach in the treatment of NMO is provided, as clobetasol increased the number of mature oligodendrocytes within lesions without significantly altering initial astrocyte damage or inflammation. Expand
Identification and functional analysis of ligands for natural killer cell activating receptors in colon carcinoma.
TLDR
expression of DNAM-1 and NKG2D was reduced in NK cells of colon cancer patients, and this reduction could directly suppress the activation of NK cells, ultimately leading to the inhibition of NK cytotoxicity. Expand
Bystander mechanism for complement-initiated early oligodendrocyte injury in neuromyelitis optica
TLDR
Evidence for a complement ‘bystander mechanism’ to account for early oligodendrocytes injury in NMO is reported, in which activated, soluble complement proteins following AQP4-IgG binding to astrocyte AQP 4 result in deposition of the complement membrane attack complex (MAC) on nearby oligod endocrine cells. Expand
Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats
TLDR
The results establish a rat model ofUT inhibition and demonstrate the diuretic efficacy of UT inhibition, and DMTU treatment prevented hyponatremia and water retention produced by water-loading in dDAVP-treated rats. Expand
Formation of multicellular epithelial structures.
TLDR
It is found that expression of a dominant-negative form of the small GTPase Rac1 causes an inversion of epithelial polarity, such that the apical surface of the cells instead faces the periphery of the cyst, indicating that the establishment of polarity and the orientation ofPolarity can be experimentally separated by growing cells in a 3D collagen gel. Expand
Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.
TLDR
The analog set systematically explored modifications of substituents on the thiourea including alkyl, heterocycles and phenyl rings, with different steric and electronic features, and had a wide range of inhibition activities and selectivities. Expand
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