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UNLABELLED The software tool PBEAM provides a parallel implementation of the BEAM, which is the first algorithm for large scale epistatic interaction mapping, including genome-wide studies with hundreds of thousands of markers. BEAM describes markers and their interactions with a Bayesian partitioning model and computes the posterior probability of each(More)
Wernicke's encephalopathy (WE) is a severe neurological disorder caused by thiamine deficiency. Clinically, it is most frequently observed in people with alcohol abuse. WE, however, can occur in any clinical condition associated with malnutrition or thiamine deficiency. We present the case of a 47-year-old woman with prolonged therapeutic fasting who(More)
A large quantity of ultrafine tetragonal barium titanate (BaTiO3) nanoparticles is directly synthesized at room temperature. The crystalline form and grain size are checked by both X-ray diffraction and transmission electron microscopy. The results revealed that the perovskite nanoparticles as fine as 7 nm have been synthesized. The phase transition of the(More)
BACKGROUND Alternative splicing expands transcriptome diversity and plays an important role in regulation of gene expression. Previous studies focus on the regulation of a single cassette exon, but recent experiments indicate that multiple cassette exons within a gene may interact with each other. This interaction can increase the potential to generate(More)
Recent studies suggest that copy number variations (CNVs) are also involved in the genetic risk of schizophrenia. Using a Cochran-Mantel-Haenszel (CMH) adjusted meta-analysis in 18,497 schizophrenia patients and 25,522 healthy controls from 14 independent samples, we conducted replication analyses of four chromosomal deletions at 1q21.1, 15q11.2, 15q13.3,(More)
An annual runoff forecasting method is presented based on unit root test, cointegration test and error correction model of the upper and lower reaches of the Second Songhua River. The method of cointegration analysis is applied to the annual runoff data of the Baishan and Fengman hydrology Stations; then the error correction model is set up, which can(More)
We re-sampled and permutated the EST evidence to make sure of two things: 1) the bias toward positive values in the distribution of correlation coefficient is not an artifact of small, discrete value of EST numbers; 2) the peaks on-1 and +1 in the distribution are not artifacts of biased distribution of correlation coefficients. These procedures were(More)
Genome-wide analysis (GWA) is an effective strategy to discover extreme effects surpassing genome-wide significant levels in studying complex disorders; however, when sample size is limited, the true effects may fail to achieve genome-wide significance. In such case, there may be authentic results among the pools of nominal candidates, and an alternative(More)
In this study, we aimed at investigating the association between glutathione-S-transferase (GSTM1 and GSTT1) deletion genotypes and susceptibility to non-arteritic anterior ischemic optic neuropathy (NAION). We hope our findings may contribute to the understanding NAION pathogenesis and provide some clues for the prevention and treatment of optic diseases.(More)
Er<sup>3+</sup> doped tellurite glasses are promising candidates for potential broadband optical amplier and tunable fiber lasers because of their excellent optical properties. The emission spectrum show that their FWHM around 1.5 ¿m is about 50 nm which is almost twice as broad as the corresponding spectrum in silica. The lifetime of the(More)