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A set of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors was investigated with the aim of developing 3D-QSAR models using the Flexible Atom Receptor Model (FLARM) method. Some 3D-QSAR models were built with high correlation coefficients, and the FLARM method predicted the biological activities of compounds in test set well. The FLARM(More)
Cancer initiating cells have been documented in multiple myeloma and believed to be a key factor that initiates and drives tumor growth, differentiation,metastasis, and recurrence of the diseases. Although myeloma initiating cells (MICs) are likely to share many properties of normal stem cells, the underlying mechanisms regulating the fate of MICs are(More)
Based on Restricted Boltzmann Machines (RBMs), an improved pseudo-stochastic sequential cipher generator is proposed. It is effective and efficient because of the two advantages: this generator includes a stochastic neural network that can perform the calculation in parallel, that is to say, all elements are calculated simultaneously; unlimited number of(More)