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OBJECTIVE/METHOD A series of 4H-chromen-4-one derivatives (A1-A16) have been designed and synthesized, and they were screened for BRAF kinase inhibitory activity. Furthermore, their biological activities were evaluated in vitro. RESULT Compounds A03 and A10 displayed the most potent antiproliferative activity against human osteosarcoma cell line (U2OS)(More)
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