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To validate and extend the findings of the MicroArray Quality Control (MAQC) project, a biologically relevant toxicogenomics data set was generated using 36 RNA samples from rats treated with three chemicals (aristolochic acid, riddelliine and comfrey) and each sample was hybridized to four microarray platforms. The MAQC project assessed concordance in(More)
BACKGROUND Human infections with different avian influenza viruses--eg, H5N1, H9N2, and H7N9--have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. METHODS We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang(More)
We present a system that composes a realistic picture from a simple freehand sketch annotated with text labels. The composed picture is generated by seamlessly stitching several photographs in agreement with the sketch and text labels; these are found by searching the Internet. Although online image search generates many inappropriate results, our system is(More)
In this work, a novel nonlinear filter, called tri-state median (TSM) filter, is proposed for preserving image details while effectively suppressing impulse noise. We incorporate the standard median (SM) filter and the center weighted median (CWM) filter into a noise detection framework to determine whether a pixel is corrupted, before applying filtering(More)
Short Message Service (SMS) messages are short messages sent from one person to another from their mobile phones. They represent a means of personal communication that is an important communicative artifact in our current digital era. As most existing studies have used private access to SMS corpora, comparative studies using the same raw SMS data have not(More)
—A fundamental goal of data center networking is to efficiently interconnect a large number of servers with the low equipment cost. Several server-centric network structures for data centers have been proposed. They, however, are not truly expandable and suffer a low degree of regularity and symmetry. Inspired by the commodity servers in today's data(More)
As a promiscuous xenobiotic sensor, the constitutive androstane receptor (CAR; NR1I3) regulates the expression of multiple drug-metabolizing enzymes and transporters in liver. The constitutively activated nature of CAR in the cell-based transfection assays has hindered its use as a predictor of metabolism-based drug-drug interactions. Here, we have(More)
Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Using deep RNA profiling in different mouse tissues, we observed that circRNAs were substantially enriched in brain and a disproportionate fraction of them were derived from host genes that encode synaptic proteins. Moreover, on the basis of separate profiling of the RNAs localized in(More)