Tanzina Chowdhury

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BACKGROUND Most commonly a tissue diagnosis of rhabdomyosarcoma (RMS) in children is made by biopsy as opposed to primary resection. Open surgical procedures are often recommended to obtain sufficient material for accurate and complete diagnostic work up. Our institution has routinely used image-guided needle biopsies for soft tissue tumour diagnosis. We(More)
Translocations involving the Mixed Lineage Leukemia (MLL) gene at 11q23 are found in both acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML), but have different prognostic implications depending on the phenotype of the leukemia in de novo pediatric cases. The majority of MLL gene rearrangements are associated with infant ALL, and their(More)
Forty percent of renal cell carcinomas (RCCs) in childhood are characterized by translocation involving transcription factor E3 (TFE3) family members. Here, we describe a case of TFE3-positive RCC in which metastatic relapse to the mediastinal lymph nodes and pulmonary nodules was treated with single-agent sunitinib, a multitargeted tyrosine inhibitor.(More)
Infantile fibrosarcoma (IFS) is a malignant neoplasm, arising in children younger than 2 years of age and with a hallmark chromosomal translocation t(12;15)(p13;q26) encoding an ETV6-NTRK3 fusion oncoprotein. A review of the world literature found no reported cases of molecularly proven IFS with distant metastatic spread at presentation. We report the case(More)
Redox-active organic compounds have been studied as corrosion inhibitors for steel. Even though it is clear that chemical interactions at the organic−metal oxide interface are behind this inhibitive process, the detailed mechanism is not yet fully understood. Using phenyl-capped aniline tetramer (PCAT), we have elucidated the interactions at the interface(More)
Background Late cardiotoxicity is a known complication of anthracycline therapy. CMR is the gold standard for assessment of cardiac function, with demonstrated utility in the detection of subtle abnormalities of myocardial structure and motion. Using conventional and novel CMR techniques, we re-examined a cohort of late cancer survivors, previously studied(More)
PURPOSE To analyze the long-term visual acuity, strabismus, and nystagmus outcomes in Group D retinoblastoma following multimodality treatments in a national retinoblastoma referral center. DESIGN Retrospective interventional case series. METHODS A 13-year retrospective chart review of Group D eyes treated initially with intravenous chemotherapy (IVC)(More)
BACKGROUND Eye salvage rate for group D retinoblastoma using intravenous chemotherapy (IVC) as a primary modality is <50%. To report on 13 years' experience with the use of primary IVC for group D retinoblastoma. METHODS A retrospective analysis of 64 group D eyes (52 patients) treated with primary IVC, from 2002 to 2014. RESULTS The median age at(More)
Selection of the most appropriate chemotherapy dosing regimens for neonates treated within the first weeks of life represents a significant clinical dilemma. Due to a lack of information relating to the clinical pharmacology of anticancer drugs in these challenging patients, current dosing guidelines are based on limited scientific rationale. In the current(More)