Tanveer A. Bhuiyan

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Drug-induced triangulation of the cardiac action potential is associated with increased risk of arrhythmic events. It has been suggested that triangulation causes a flattening of the electrocardiographic T-wave but the relationship between triangulation, T-wave flattening and onset of arrhythmia has not been studied in detail. In this paper, we have(More)
Introduction: The first heart sound (S1) carries information about ventricular function which may be clinically useful in optimization of cardiac resynchronization therapy (CRT). We developed a method of measuring the effects of CRT on S1 energy. Methods: For 10 patients with activation induced heart failure (age 64±8.4 years), the heart sound was(More)
It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker(More)
The fertilized chicken egg (embryonic chicken) shares the basic mechanism of electrophysiology and ionic currents with mammalian hearts. However, little is known about the cardiac repolarization process during embryo growth. We examined if the electrocardiographic QT interval was dependent on the stage of embryonic development. ECGs were recorded from 4(More)
Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened T-wave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of(More)
BACKGROUND AND OBJECTIVE The T-peak to T-end (TpTe) interval has been suggested as an index of transmural dispersion and as a marker of drug-induced abnormal repolarization. In this study, we investigate the relation between TpTe and the QT interval. METHODS Electrocardiograms (ECGs) from five different drugs (sotalol, sertindole, moxifloxacin, nalmefene,(More)
Traditional apex-cardiography measures chest wall vibrations at the apex beat using an air-coupled microphone. To provide additional insight in apexcardiography and chest vibrations we estimated the three dimensional displacement of the apex beat. A 3-axis accelerometer was placed at the location of the apex beat in 5 healthy subjects in left lateral(More)
The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave(More)
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