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Beta-adrenergic stimulation suppresses phagocytosis via Epac activation in murine microglial cells
Endogenous noradrenaline presumably prohibits neuroinflammation by stimulation of β-adrenergic receptor-dependent suppression of the production of inflammatory mediators. Using the microglial cell… Expand
A Swelling-Activated Chloride Current in Microglial Cells is Suppressed by Epac and Facilitated by PKA - Impact on Phagocytosis.
- Michael Kittl, M. Jakab, Tanja S. Steininger, M. Ritter, H. Kerschbaum
- Chemistry, Medicine
- Cellular physiology and biochemistry…
BACKGROUND/AIMS Volume-regulated anion channels (VRACs) are of particular importance in regulating the cell volume (CV) and give rise to the swelling-activated Cl- current (ICl,swell), a main… Expand