Tanja Grimmig

Learn More
Chronic inflammation as an important epigenetic and environmental factor for putative tumorigenesis and tumor progression may be associated with specific activation of Toll-like receptors (TLR). Recently, carcinogenesis has been suggested to be dependent on TLR7 signaling. In the present study, we determined the role of both TLR7 and TLR8 expression and(More)
BACKGROUND Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For(More)
Tumor progression results from a disrupted regulation of cell growth as well as from the failure of the host to mount an efficient antitumor immune response. Most human colorectal cancer (CRC) patients do not develop satisfactory antitumor immune responses, pointing to the existence of strategies whereby CRCs evade immune effectors. CD4CD25 regulatory T(More)
Platelet-derived growth factor (PDGF) and signaling via its receptors plays a crucial role in tumor cell proliferation and thus may represent an attractive target besides VEGF/EGFR-based antibody therapies. In this study we analyzed the influence of PDGF in colorectal cancer. PDGF was expressed intensively in early and even more intensively in late stage(More)
Toll like receptor (TLR) signaling has been suggested to play an important role in the inflammatory microenvironment of solid tumors and through this inflammation-mediated tumor growth. Here, we studied the role of tumor cells in their process of self-maintaining TLR expression independent of inflammatory cells and cytokine milieu for autoregulative tumor(More)
Purpose: The programmed death-1/programmed death ligand (PD-1/PD-L) pathway in T cell activation has been shown to play an important role in tumor evasion from host immunity. The predictive value of PD-L1 and PDL2 expression in colorectal cancer (CRC) remains still under discussion. We analyzed whether negative signaling of infiltrating PD-1-positive T(More)
e21072 Background: Peritoneal carcinosis (PC) is diagnosed in 10-20% of gastric, colorectal and ovarian cancer. Hyperthermic intraperitoneal chemotherapy (HIPEC) is increasingly integrated into multimodal treatment strategies. We analyzed relevant HSPs that confer resistance to physical stresses (elevated temperatures) as well as profiles of the specific(More)
  • 1