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PURPOSE The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic inbred strain LEW.1AR1 (RT1(r²)). In contrast to the diabetes-resistant LEW.1AR1 background strain in LEW.1AR1-iddm rats a highly variable T-cell frequency could be observed in peripheral blood(More)
The therapeutic capacity of an antibody directed against the T cell receptor (anti-TCR) of the TCR/CD3 complex alone or in combination with fingolimod (FTY720) to reverse the diabetic metabolic state through suppression of autoimmunity and stimulation of β cell regeneration was analyzed in the LEW.1AR1-iddm (IDDM) rat, an animal model of human type 1(More)
The top quark pair production cross section is measured for the first time in proton-proton collisions at sqrt[s]=13  TeV by the CMS experiment at the CERN LHC, using data corresponding to an integrated luminosity of 43  pb^{-1}. The measurement is performed by analyzing events with at least one electron and one muon of opposite charge, and at least two(More)
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