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Structure of a Prokaryotic Virtual Proton Pump at 3.2 Å Resolution
To reach the mammalian gut, enteric bacteria must pass through the stomach. Many such organisms survive exposure to the harsh gastric environment (pH 1.5–4) by mounting extreme acid-resistanceExpand
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A Cyclic Nucleotide Modulated Prokaryotic K+ Channel
A search of prokaryotic genomes uncovered a gene from Mesorhizobium loti homologous to eukaryotic K+ channels of the S4 superfamily that also carry a cyclic nucleotide binding domain at the COOHExpand
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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5
Aggrecanases are now believed to be the principal proteinases responsible for aggrecan degradation in osteoarthritis. Given their potential as a drug target, we solved crystal structures of the twoExpand
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Fluoride resistance and transport by riboswitch-controlled CLC antiporters
A subclass of bacterial CLC anion-transporting proteins, phylogenetically distant from long-studied CLCs, was recently shown to be specifically up-regulated by F-. We establish here that a set ofExpand
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Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.
MAP KAP kinase 2 (MK2), a Ser/Thr kinase, plays a crucial role in the inflammatory process. We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2,Expand
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Intracellular Proton Access in a Cl−/H+ Antiporter
Mutagenesis, functional analysis, and crystal structures identify a watery tunnel through which protons enter the interior of a Cl−/H+ antiport protein involved in acid resistance of enteric bacteria.
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Crystal structures of a double-barrelled fluoride ion channel
To contend with hazards posed by environmental fluoride, microorganisms export this anion through F−-specific ion channels of the Fluc family. Since the recent discovery of Fluc channels, numerousExpand
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W-Band ENDOR Investigation of the Manganese-Binding Site of Concanavalin A: Determination of Proton Hyperfine Couplings and Their Signs
W-band (95 GHz) pulsed EPR and electron−nuclear double resonance spectroscopic techniques were used to investigate the manganese S1 binding site of the protein concanavalin A in a frozen solution andExpand
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Applications of focused ion beams in microelectronics production, design and development
Focused ion beam (FIB) systems using gallium liquid metal ion sources can remove material with a lateral resolution below 50 nm and can produce metal deposition at a similar resolution with ionExpand
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Geometry and Framework Interactions of Zeolite-Encapsulated Copper(II)-Histidine Complexes
The coordination geometry of zeolite-encapsulated copper(II)-histidine (CuHis) complexes, prepared by ion exchange of the complexes from aqueous solutions into zeolite NaY, was determined by aExpand
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