Tania Rodriguez-Cruz

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T cells expressing chimeric antigen receptors (CARs) or the infusion of bispecific T-cell engagers (BITEs) have shown antitumor activity in humans for CD19-positive malignancies. While BITEs redirect the large reservoir of resident T cells to tumors, CAR T cells rely on significant in vivo expansion to exert antitumor activity. We have shown that it is(More)
Glioblastoma (GBM) is the second most common, but most aggressive, primary brain tumor. Despite aggressive multimodal therapy consisting of surgery, radiation, and chemotherapy, the outcome of patients with GBM remains poor with 5-year survival rates of <10%. Therefore , new, targeted treatments are needed to improve outcomes , and adoptive T cell(More)
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