Tania Dexter

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Pleomorphic lobular carcinomas (PLC) of the breast display histological features associated with classic invasive lobular carcinoma (ILC), yet they also exhibit more conspicuous nuclear atypia and pleomorphism, and an aggressive clinical behaviour. From a breast cancer progression perspective, it is unclear whether PLC is a variant of ILC or is a high-grade(More)
We analysed the molecular genetic profiles of breast cancer samples before and after neoadjuvant chemotherapy with combination doxorubicin and cyclophosphamide (AC). DNA was obtained from microdissected frozen breast core biopsies from 44 patients before chemotherapy. Additional samples were obtained before the second course of chemotherapy (D21) and after(More)
Heavy menstrual bleeding is a common presenting complaint and can significantly affect the quality of life of affected women. The 2007 National Institute for Clinical Excellence guideline on heavy menstrual bleeding states that in women with heavy menstrual bleeding alone, endometrial ablation should be considered preferable to hysterectomy. The choice of(More)
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