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Genetic linkage data have shown that alterations of the BRCA1 gene are responsible for the majority of hereditary breast-ovarian cancers. However, BRCA1 germline mutations are found much less frequently than expected, especially as standard PCR-based mutation detection approaches focus on point and small gene alterations. In order to estimate the(More)
This paper presents work towards recognizing facial expressions that are used in sign language recognition. Facial features are tracked to effectively capture temporal visual cues on the signer's face during signing. A Bayesian framework is proposed as a feedback mechanism to the Kanade-Lucas-Tomasi (KLT) tracker for reliably tracking facial features in the(More)
PET is a crucial technique in molecular imaging, allowing in vivo assessment and localization of pathological processes, thanks to its ability to detect very small amounts of radioactive molecules. This is of particular interest in oncology where abnormal metabolism or synthesis in tumor cells but also various tumor characteristics can be studied using this(More)
CONTEXT Providing accurate estimates of cancer risks is a major challenge in the clinical management of Lynch syndrome. OBJECTIVE To estimate the age-specific cumulative risks of developing various tumors using a large series of families with mutations of the MLH1, MSH2, and MSH6 genes. DESIGN, SETTING, AND PARTICIPANTS Families with Lynch syndrome(More)
BACKGROUND To asses the clinical profile, treatment outcome and prognostic factors in primary breast lymphoma (PBL). METHODS Between 1970 and 2000, 84 consecutive patients with PBL were treated in 20 institutions of the Rare Cancer Network. Forty-six patients had Ann Arbor stage IE, 33 stage IIE, 1 stage IIIE, 2 stage IVE and 2 an unknown stage.(More)
PURPOSE To evaluate the role of postoperative radiotherapy (RT) in Merkel cell carcinoma (MCC). METHODS AND MATERIALS A retrospective multicenter study was performed in 180 patients with MCC treated between February 1988 and September 2009. Patients who had had surgery alone were compared with patients who received surgery and postoperative RT or radical(More)
PURPOSE To assess the outcomes and patterns of failure in solitary plasmacytoma (SP). METHODS AND MATERIALS The data from 258 patients with bone (n = 206) or extramedullary (n = 52) SP without evidence of multiple myeloma (MM) were collected. A histopathologic diagnosis was obtained for all patients. Most (n = 214) of the patients received radiotherapy(More)
PURPOSE Primary bone lymphoma (PBL) represents less than 1% of all malignant lymphomas. In this study, we assessed the disease profile, outcome, and prognostic factors in patients with Stages I and II PBL. PATIENTS AND METHODS Thirteen Rare Cancer Network (RCN) institutions enrolled 116 consecutive patients with PBL treated between 1987 and 2008 in this(More)
In American Sign Language (ASL) the structure of signed sentences is conveyed by grammatical markers which are represented by facial feature movements and head motions. Without recovering grammatical markers, a sign language recognition system cannot fully reconstruct a signed sentence. However, this problem has been largely neglected in the literature. In(More)