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Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands
TLDR
In DNA–targeting CRISPR/Cas systems, chromosomal interference is deleterious by causing DNA damage and providing a strong selective pressure for genome alterations, which may have consequences for bacterial evolution and pathogenicity.
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PigS and PigP Regulate Prodigiosin Biosynthesis in Serratia via Differential Control of Divergent Operons, Which Include Predicted Transporters of Sulfur-Containing Molecules
TLDR
Divergently transcribed from pigS-pmpABC is a bicistronic operon, which encodes a metallo-β-lactamase and a coenzyme A-disulfide reductase containing a rhodanese homology domain, both of which may participate in reactions with sulfur-containing compounds.
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Anticancer and immunosuppressive properties of bacterial prodiginines.
TLDR
Bacterial prodiginines and synthetic derivatives are effective proapoptotic agents with multiple cellular targets, and they are active against numerous cancer cell lines, including multidrug-resistant cells, with little or no toxicity towards normal cell lines.
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Csy4 is responsible for CRISPR RNA processing in Pectobacterium atrosepticum
TLDR
This study provides the first in vivo evidence that the CRISPR endoribonuclease Csy4 generates crRNAs in its native host and characterizes the operonic transcription of the cas cluster.
View on Taylor & Francis
In Vivo Protein Interactions and Complex Formation in the Pectobacterium atrosepticum Subtype I-F CRISPR/Cas System
TLDR
Results show that the subtype I-F Cas1 and Cas3 (a Cas2-Cas3 hybrid) proteins interact, suggesting a protein complex for adaptation and a role for sub type I-f Cas3 proteins in both the adaptation and interference steps of the CRISPR/Cas mechanism.
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The PhoBR two-component system regulates antibiotic biosynthesis in Serratia in response to phosphate
TLDR
It is demonstrated that expression of rap, pigA-O and smaI are controlled via PhoBR in Serratia 39006, incorporating transcriptional control mediated by three important global regulators, PhoB, SmaR and Rap.
View on Springer
The sub-cellular localization of Sulfolobus DNA replication
TLDR
The generation of strains of Sulfolobus solfataricus and Sulfoobus acidocaldarius that allow the incorporation of nucleoside analogues during DNA replication are described and a peripheral localization of replisomes in the cell is revealed.
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Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM
TLDR
This work reveals functional conservation of this architecture despite the 2 billion-year evolutionary gulf between archaea and eukaryotes and demonstrates that the homohexameric archaeal MCM helicase associates with orthologs of GINS and Cdc45 in vivo and in vitro.
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Identification and characterization of a heterotrimeric archaeal DNA polymerase holoenzyme
TLDR
It is revealed that the highly studied PolB1 from Sulfolobus solfataricus exists as a heterotrimeric complex in cell extracts and the architecture of the assembly is revealed by a combination of cross-linking coupled with mass spectrometry, X-ray crystallography and single-particle electron microscopy.
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PigZ, a TetR/AcrR family repressor, modulates secondary metabolism via the expression of a putative four‐component resistance‐nodulation‐cell‐division efflux pump, ZrpADBC, in Serratia sp. ATCC 39006
TLDR
Bioinformatic analysis revealed that putative RND efflux pumps encoding two MFP components are not uncommon, particularly among plant‐associated, Gram‐negative bacteria, and it is proposed that these pairs of MFPs consist of two distinct subtypes.
View on Wiley
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