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Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.

• S. Y. Zhang, Andres Jp Klein-Szanto, +6 authors Tamra L. Goodrow
• Cancer research
• 1994

Sixty-eight primary head and neck squamous cell carcinomas and nine head and neck squamous cell carcinoma cell lines were examined for mutations and homozygous deletions of the p16/CDKN2 gene.… (More)

p53 protein accumulation and gene mutation in the progression of human prostate carcinoma.

• Nora M. Navone, P. Brunny Troncoso, +5 authors Claudio J. Conti
• Journal of the National Cancer Institute
• 1993

BACKGROUND Nuclear accumulation of p53 protein has been shown to be strongly associated with missense p53 mutations. Studies of nuclear accumulation of p53 protein in prostate carcinoma cells have to… (More)

Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.

• Bruce A. Ruggeri, M. DiRado, S. Y. Zhang, B. Bauer, Tamra L. Goodrow, Andres Jp Klein-Szanto
• Proceedings of the National Academy of Sciences…
• 1993

Human tobacco-related cancers exhibit a high frequency of G to T transversions in the mutation hot spot region of the p53 tumor suppressor gene, possibly the result of specific mutagens in tobacco… (More)

The mouse lymphoma L5178Y Tk+/- cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene.

• Richard D Storer, Andrew R Kraynak, Troy W McKelvey, Massimo Elia, Tamra L. Goodrow, J G Deluca
• Mutation research
• 1997

The p53 tumor suppressor protein plays an important role in regulating the cellular response to DNA damage, including cell cycle arrest and apoptosis induction. Normal p53 function is critical for… (More)

Deletion and mutation analyses of the P16/MTS-1 tumor suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal…

• L. Huang, Tamra L. Goodrow, S. Y. Zhang, Andres Jp Klein-Szanto, H. Chang, Bruce A. Ruggeri
• Cancer research
• 1996

The putative tumor suppressor gene p16/CDKN2 encodes a specific inhibitor of cyclin D-cyclin-dependent kinase 4 complexes important in cell-cycle regulation and has been found to be deleted or… (More)

Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.

• Tamra L. Goodrow, Sheila Reynolds, ROBERT. R. MARONPOT, M. Anderson
• Cancer research
• 1990

1,3-Butadiene has been detected in urban air, gasoline vapors, and cigarette smoke. It has been estimated that 65,000 workers are exposed to this chemical in occupational settings in the United… (More)

Overexpression of the calcium sensor visinin-like protein-1 leads to a cAMP-mediated decrease of in vivo and in vitro growth and invasiveness of squamous cell carcinoma cells.

• Haleh Mahloogi, Anatilde M. Gonzalez-Guerrico, +4 authors Andrés J. P. Klein-Szanto
• Cancer research
• 2003

Visinin-like protein-1 (VILIP-1) is a member of the neuronal EF-hand Ca(2+)-sensor protein family. VILIP-1 is expressed in the central nervous system where it plays a crucial role in regulating cAMP… (More)

Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms.

• S. Y. Zhang, S. C. Liu, Tamra L. Goodrow, R. Morris, Andres Jp Klein-Szanto
• Molecular carcinogenesis
• 1997

Cyclins and cyclin-dependent kinases (Cdks) are central to regulation of the cell cycle. Their abnormal expression may cause loss of cell-cycle control and result in autonomous cell growth, a… (More)

Analysis of the FHIT gene and its product in squamous cell carcinomas of the head and neck

• Anne E. Kisielewski, G. H. Xiao, +6 authors Tamra L. Goodrow
• Oncogene
• 1998

The FHIT gene has been implicated as a tumor suppressor gene in human malignancies. To determine if FHIT alterations play a role in human squamous cell carcinogenesis of the head and neck (HNSCC), we… (More)

The FHIT gene product is highly expressed in the cytoplasm of renal tubular epithelium and is down-regulated in kidney cancers.

• G. H. Xiao, Feng Jin, Andres Jp Klein-Szanto, Tamra L. Goodrow, Mark Linehan, R Yeung
• The American journal of pathology
• 1997

Loss of heterozygosity and homozygous deletion of the 3p14.2 region in human cancers implies the existence of a tumor suppressor gene. One such candidate is the fragile histidine triad (FHIT) gene.… (More)

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