Tamjidul Hoque

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This paper presents the impact of twins and the measures for their removal from the population of genetic algorithm (GA) when applied to effective conformational searching. It is conclusively shown that a twin removal strategy for a GA provides considerably enhanced performance when investigating solutions to complex ab initio protein structure prediction(More)
This paper describes a detailed investigation of a lattice-based HP (hydrophobic-hydrophilic) model for ab initio protein structure prediction (PSP). The outcome of the simplified HP lattice model has high degeneracy, which could mislead the prediction. The HPNX model was proposed to address the degeneracy problem as well as to avoid the conformational(More)
In this paper, we present a new genetic algorithm for protein structure prediction problem using face-centred cubic lattice and hydrophobic-polar energy model. Our algorithm uses i) an exhaustive generation approach to diversify the search; ii) a novel hydrophobic core-directed macro move to intensify the search; and iii) a random-walk strategy to recover(More)
— Proteins carry out the majority of functionality on a cellular level. Computational protein structure prediction (PSP) methods have been introduced to speed up the PSP process due to manual methods, like nuclear magnetic resonance (NMR) and x-ray crystallography (XC) taking numerous months even years to produce a predicted structure for a target protein.(More)