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The time intervals measured from the administration of either atracurium or vecuronium to maximum or 95% neuromuscular blockade (Tmax) were compared in 70 patients using the evoked compound action potential of the adductor pollicis muscle. Equipotent doses, calculated from the relationship between dose and response for both drugs obtained in an earlier(More)
Thirty-two inbred Wistar rats (study group) were exposed to trichloroethylene 100 p.p.m. in air for 4 h daily from day 8 to day 21 of pregnancy. A control group (31 rats) was exposed to the same experimental conditions but without the addition of trichloroethylene. All the rats were sacrificed on the 21st day of pregnancy and the ovaries, uterus, liver,(More)
This study was designed to test if changes in the degree of respiratory sinus arrhythmia (RSA) can be used as an index of light anaesthesia. An on-line, real-time data logging system was used to record simultaneously the EEG and ECG waveforms from 10 patients undergoing routine surgery using i.v. propofol (Diprivan) anaesthesia. The degree of RSA was(More)
A relatively small dose of rocuronium (0.45 mg kg-1) was compared with equipotent doses of atracurium (0.35 mg kg-1) and vecuronium (0.075 mg kg-1) for ease of intubation at 60 s. All patients could be intubated but the proportion with excellent or good conditions was much greater with rocuronium. Mean clinical duration of effect of this dose was 22.2 min.(More)
In a double-blind investigation the effect of oral controlled-release morphine (MST 30 mg) on pre-operative anxiety was assessed in 50 patients undergoing cholecystectomy. The effects on anaesthetic requirements and recovery, and postoperative pain were also studied. The patients who received morphine treatment were more sedated than those who received the(More)
The effects of neostigmine, and of neostigmine with adrenaline, on the response of the rat isolated hemidiaphragm to stimulation of the phrenic nerve are reported. Neostigmine augmented the response: a maximum augmentation occurred at a concentration of 6.4 X 10(-7) mol litre-1. At greater concentrations of neostigmine the response was reduced. Adrenaline(More)
The effects of atracurium and alcuronium on the evoked mechanical and electromyographic responses of the adductor pollicis were investigated in 30 adult patients. The ulnar nerve was stimulated with trains of four supramaximal pulses of 0.2 ms duration and a frequency of 2 Hz at intervals of 20 s. The mechanical response was measured using a strain gauge(More)
A prolonged electrocardiographic QT interval may be harmful during general anaesthesia. It may be prudent, therefore, to select anaesthetic agents which have the least effect on the QT interval. In a controlled study, propofol has been shown to have less effect on the QT interval than thiopentone (P less than 0.05). Our data suggest also that any effects(More)
A randomized, double-blind comparison of nalbuphine 30 mg or 60 mg by mouth and dihydrocodeine 30 mg by mouth was conducted in 75 patients with moderate to severe pain after surgery for dental extractions under general anaesthesia. A significant reduction in pain intensity followed each treatment and persisted throughout the 4-h observation period after(More)