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GYKI 52466 [1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine], a non-competitive AMPA [alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate] and kainate receptor antagonist and its two analogues, GYKI 53405 [1-(4-aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine] and GYKI 53655(More)
BACKGROUND AND PURPOSE Functional stimulation is accompanied by increases in regional cerebral blood flow which exceed metabolic demands under normal circumstances, but it is unknown whether functional stimulation is beneficial or detrimental in the setting of acute ischemia. The aim of this study was to determine the effect of forepaw stimulation during(More)
Spreading depolarizations are accompanied by transient changes in cerebral blood flow (CBF). In a post hoc analysis of previously studied control rats we analyzed CBF time courses after middle cerebral artery occlusion in the rat in order to test whether intra-ischemic flow, reperfusion, and different parameters of peri-infarct flow transients (PIFTs)(More)
Evolutionary pressures, viruses as nature's genetic engineering tools and T cell surveillance emergence for purging nascent selfish cells " It is not the strongest of the species that survives, nor the most intelligent, but the one most responsive to change. " Charles Darwin Summary The US and Hungarian statistical records, before the dramatic medical(More)
Our main tenet argues that the primary role of positive thymic selection and the resulting T cell population is the maintenance of a homeo-static equilibrium with self MHC-self peptide complexes. The homeostatic T cell repertoire can recognize infections non-specifically and this is an indirect (negative) recognition: the whole homeostatic T cell population(More)
On the basis of their earlier experiments the authors assumed that the ability to recognize the smell of two ketone compounds, acetone and methylethylketone (MEK), might be determined genetically. In the present work of smelling test was performed in adult Hungarian twins, 61 like sexed DZ pairs and 87 MZ pairs. No connection was found between twin zygosity(More)
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