Tamara S. Gan'shina

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The tripeptide Glu-His-Pro-NH2, a hypothalamic neurohormone (thyrotropin releasing hormone), sometimes called thyroliberin, according to observations made by many workers has a central stimulating antidepressant, analeptic action [8, 9]. This paper gives the results of a combined pharmacological study of thyrotropin releasing hormone (TRH). The effect of(More)
Experiments on rats showed that mexidol significantly increases local cerebral blood flow in animals under conditions of global transient brain ischemia, whereas in intact rats this drug initially causes a decrease in the blood flow, followed by its recovery. Mechanism of the cerebrovascular effect of mexidol is determined by its action on GABA receptors of(More)
The effects of GABA - docosahexaenoyldopamine (DHED) conjugate on the cerebral haemodynamics and thrombocyte aggregation were evaluated and compared to these of docosahexaenoyldopamine alone. The GABA - DHED conjugate was shown to significantly enhance the cerebral circulation in rats with a model of global transient cerebral ischemia, as compared to the(More)
In most experiments on rats under conditions of cerebral global transient ischemia, melatonin substantially enhanced local blood flow and decreased arterial blood pressure. In intact rats, the effect of melatonin on brain perfusion was much less pronounced and the arterial pressure was not influenced at all. The mechanism of melatonin action has been(More)
Thermoprotector properties of a 1 : 1 combination of sydnocarb and ladasten (both in a dose of 10 or 20 mg/kg) along with its effect on the hemodynamics and respiration in experimental animals were studied. The combination of sydnocarb (20 mg/kg) and ladasten (20 mg/kg) produced a significant thermoprotector effect, enhanced the regional and local cerebral(More)
Naloxone was shown to induce a slight increase of the blood supply to the brain, an elevation of blood pressure and an enhancement of the bioelectrical activity in the sympathetic nerves. Unlike opioid peptides, naloxone was found to exert a marked alleviating effect on the nervous control of the cerebral circulation. The drug increases neurogenic spasms of(More)
Thyroliberin increases the cerebral blood flow both in anesthesized cats and unanesthetized rabbits under hemorrhagic shock. At the same time the increase of the arterial pressure is observed, caused by activation of the sympathoadrenal system. This is confirmed by experiments with the removal of the hypertensive reaction to thyroliberin after the use of(More)
The effect of serotonin on the brain blood supply was studied in rats before and after ischemic damage. The ischemic damage, induced by ligation of the middle meningeal artery, markedly enhanced the constrictor effect of serotonin on the brain vessels. Tropoxin, a 5HT2 receptor blocker, completely eliminated these cerebrovascular effects of serotonin.
Narcotized rats under hemorrhagic stroke model conditions exhibit a significant decrease in the cerebral flow in the region of contralateral cerebral hemisphere symmetric to the zone of lesion. Under these conditions, afobazole produced a significant increase in the local circulation in cerebral cortex, which was violated by hemorrhagic stroke. The(More)
3. V.V. Lyskovtsev, Z. P. Senova, I. A. Yuryavichyus, et. al., Byull. Eksp. Biol. fled., No. 3, 243 (1979). 4~ L.V. Rozenshtraukh, R. L. Ver'e, and B. Lown, Vestn. Akad. fled. Nauk SSSR, No. i0, 52 (1978). 5o L.V. Rozenshtraukh, R. Raffi, V. Elkharar, et al., Kardiologiya, No. 5, 63 (1979). 6. L.V. Rozenshtraukh, V. A. Saks, I. A. Yuryavichyus, et al.,(More)